Effect of natural antioxidants on lead toxicity in rats

The present study was conducted on 40 male albino rats to study the effect of combined oral administration of three natural antioxidants [vitamin E, A and C] on different parameters during one month oral lead intoxication. The animals were divided into four groups: Group one and two were considered as controls as they received sodium acetate 400 mg/kg/day in group one or sodium acetate plus 2% gum acacia + 1 ml distilled water in group two, group three received lead acetate and group four received lead acetate plus a combination of the three vitamins. It was observed that administration of the combination of the three vitamins significantly improved the toxic manifestations of lead in group three

Effect of natural antioxidants on lead toxicity in rats; histological and histochemical assessment of the liver

The present study was conducted on 40 adult male albino rats divided into four4 equal groups. Groups I and II were used as controls, they received 1 ml distilled water in group I, or sodium acetate 400 mg/kg/day orally in group II. Group III received lead acetate 400 mg/kg/day orally and group IV received lead acetate plus a combination of the 3 natural antioxidant vitamins E [100 mg/kg/day], A [7500 IU/kg/day] and C [1000 mg/kg/day]. Results showed that, the toxic manifestations of lead in group III, cellular degeneration, proliferation, widening of hepatic sinusoids, infiltration and decreased activity of lactic dehydrogenase [LD], succinic dehydrogenase [SD], and adenosine triphosphatase [ATP-ase] enzymes, were greatly improved in group IV. It can be concluded that the combination of the three antioxidant vitamins [E, A and C] seemed to have a remarkable effect in improving the hazards of lead intoxication